Alec Baldwin [8.17-18] - Parker
Helen Baxendale [4.14-19, 4.21-24, 5.1, 5.4, 5.6, 5.20] - Emily Waltham
Catherine Bell [2.6] - Robin
Selma Blair [9.10] - Wendy
Richard Branson [4.23] - vânzător
Dan Castellaneta [2.12] - îngrijitorul de la grădina zoologică
Alexis, Paul, Justin și Cole Cimoch [6.5] - Frank Jr. Jr., Leslie și Chandler Buffay
George Clooney [1.17] - Dr. Michael Mitchell
Tom Conti [4.24], 5.1] - Stephen Waltham.
Jennifer Coolidge [10.3] - Amanda
Robert Costanzo [1.13] - Joseph Tribbiani Sr.
Billy Crystal [3.24] - Tim
Kristin Davis [7.7] - Erin
E.G. Daily [3.14] - Leslie

Danny DeVito [10.11] - Roy
Morgan Fairchild [1.11, 5.8, 7.23-24, 8.1] - Nora Tyler Bing
Dakota Fanning [10.14] - Mackenzie
Anna Faris [10.9, 10.13, 10.16, 10.19] - Erica
Jon Favreau [3.18-19, 3.21-25] - Pete Becker
Sherilyn Fenn [3.14] - Ginger
Sarah Ferguson [4.23] - ea însăși
Soleil Moon Frye [5.15] - Katie
June Gable [2.10,2.19,3.22,5.10,6.4,6.21,7.19,8.22,10.4] - Estelle Leonard
Beverly Garland [1.18]- Aunt Iris
Teri Garr [3.25, 4.1, 4.11] - Phoebe Abbott
Kyle Gass [9.15] - Lowell
Melissa George [9.12, 9.13]- Molly
Todd Glass [5.23]
Paul Gleason [6.15-16] - Jack
Adam Goldberg [2.17, 2.19] - Eddie Menuek
Jeff Goldblum [9.15] - Leonard Haze
Jill Goodacre [1.7] - ea însăși
Elliott Gould [1.2, 1.8, 1.17, 2.14, 2.16, 3.1, 4.24, 5.1, 5.8, 6.9, 7.2-3, 7.13-14, 7.24-25, 8.1, 8.18, 9.1, 10.4] - Jack Geller
Jennifer Grey [1.20] - Mindy
Charlton Heston [4.14]- el însuși
Alexandra Holden [6.18, 6.19, 6.21, 6.22, 6.24] - Elizabeth Stevens
Helen Hunt [1.16] - Jamie Buchman

Chrissie Hynde [2.6] - Stephanie Schiffer
Chris Isaak [2.12] - Rob Donnen
Gregory Itzin [10.12] - Theodore Hannigan
Penn Jillette [4.3] - vânzătorul de enciclopedii
Greg Kinnear [10.6] - Benjamin Hobart
Ralph Lauren [6.8] - el însuși
Hugh Laurie [4.24] - pasager din avion
Phil Leeds [2.11] - văduva
Ron Leibman [2.22, 3.7, 8.8, 10.13] - Leonard Green
Jay Leno [1.11] - el însuși
Jon Lovitz [1.15, 9.14] - Steve
Elle Macpherson [6.7-11] - Janine Lecroix
Louis Mandylor [6.17] - Carl
Sierra Marcoux [10.2] - Chandler Buffay
Dina Meyer [3.19, 3.20, 3.22] - Kate Miller
Kevin McDonald [3.23] - Guru Saj
Sofia Milos [1.6] - Aurora
Dermot Mulroney [9.11-13] - Gavin Mitchell
Arden Myrin- Brenda
Gary Oldman [7.23-24] - Richard Crosby
Dante Pastula [10.2] - Frank Buffay Jr. Jr. Buffay
Sean Penn [8.6-7]- Eric
John Bennett Perry [4.18]- Dl. Bergen
Christina Pickles [1.2, 1.8, 2.14, 2.16, 3.1, 4.3, 4.24, 5.1, 5.8, 6.9, 7.2, 7.14, 7.23-24, 8.1, 8.12, 8.23, 9.5, 10.4] - Judy Geller

Brad Pitt [8.9]- Will Colbert
Ellen Pompeo [10.11] - Missy Goldberg
Freddie Prinze Jr. [9.6]- Sandy
Emily Procter [2.2]- Annabel
Leah Remini [1.23]- Lydia
Giovanni Ribisi [2.6, 2.21, 3.5, 3.18, 4.11-12, 4.17, 5.3, 10.2] - Frank Buffay Jr.
Denise Richards [7.19] - Cassie Geller
Julia Roberts [2.13] - Susie Moss
Rebecca Romijn [4.6] - Cheryl
Isabella Rossellini [3.5] - ea însăși
Paul Rudd [9.3-4, 9.6-7, 9.9, 9.12-13, 9.16-17, 9.23-24, 10.1, 10.5, 10.7, 10.12, 10.14, 10.19] - Mike Hannigan
Winona Ryder [7.20] - Melissa Warburton
Susan Sarandon [7.15] - Jessica Lockhart
Jennifer Saunders [4.24, 5.1] - Andrea Waltham
Tom Selleck [2.15-16, 2.18, 2.20, 2.23-24, 3.13, 6.24-25] - Richard Burke
Harry Shearer [1.21] - Dr. Baldharar
Charlie Sheen [2.23] - Ryan
Brooke Shields [2.12] - Erika Ford
Marla Sokoloff [8.10] - Dina
Bonnie Somerville [8.01, 8.05-06, 8.08, 8.11, 8.15, 8.17] - Mona
Brent Spiner [10.14] - Campbell
Cole Sprouse [6.15, 7.9-10, 7.16, 8.1, 8.10, 8.12] - Ben Geller
John Stamos [9.22] - Zach
Ben Stiller [3.22] - Tommy
Allison Sweeney [7.18] - Jessica Ashley
Christine Taylor [3.24-25, 4.1] - Bonnie
Lea Thompson [2.6] - Caroline Duffy
Ian Thorpe [7.7] - client la cafenea
Kathleen Turner [7.22-24] - Charles Bing
Aisha Tyler - [9.20-24, 10.1-2, 10.5-6] - Charlie Wheeler
Gabrielle Union [7.17] - Kristin Lang